What is COBOL, the high-level programming language that is behind biggest-ever fall in IBM stock value

AI startup Anthropic's claim of automating COBOL modernization sent IBM's stock plummeting, wiping billions off its market value. The decades-old language, still powering critical systems, faces a ...
Open Heart

Artificial intelligence-based clustering to identify functional risk phenotypes in heart failure

Background Patients with heart failure (HF) frequently suffer from undetected declines in cardiorespiratory fitness (CRF), which significantly increases their risk of poor outcomes. However, current ...
eLife

A proteome-wide biochemical screen defines binding determinants of the core autophagy protein LC3B

Human MAP1LC3B (LC3B) binds proteins involved in autophagy and other cellular processes using a degenerate four-residue short linear motif known as the LC3-interacting region (LIR). Biochemical and ...
Digital Production

Nuke 17.0 rewires 3D and adds Gaussian Splats

Nuke 17.0 adds native Gaussian Splats, USD 3D system and BigCat machine learning to Foundry’s compositing pipeline.
eLife

TAD boundary architecture and gene activity are uncoupled

A proposed function of TADs is to contribute to gene regulation by promoting chromatin interactions within a TAD and by suppressing interactions between TADs. Here, we directly probe the ...