There are a lot of practical reasons to set up an OS like Windows 10 in a VM rather than using it as a native installation. If you have to deal with files you can't trust, need to test multiple OS ...

With Disk2Vhd, you can convert Windows 10 into a virtual system without much prior knowledge. The advantage of the freeware is that it’s started directly in the Windows installation to be virtualized.

Run applications on multiple operating systems including Linux, Windows and more. Evaluate and test new operating systems, applications and patches in an isolated environment. VMware Workstation ...